Stacy’s Story

Site created on August 29, 2023

Welcome to our CaringBridge website. We will post updates related to Stacy's diagnosis of Multiple Myeloma. Stacy has written the following to update everyone on what has/is/will be happening with her treatment.


What is Multiple Myeloma? It is a cancer that forms in a type of white blood cell called a plasma cell. In multiple Myeloma, cancerous plasma cells build up in the bone marrow. Multiple Myeloma is not currently curable but can be managed effectively for years.

Back in April 2016, I had a routine blood draw to check on my Rheumatoid Arthritis (diagnosed in 2007); I had a higher-than-normal level of protein in my blood. I was referred to a hematologist. There are very specific blood tests to determine if there is a monoclonal gammopathy, and my results showed that I had levels that needed further testing. I underwent my first of many bone marrow biopsies to see if I had any abnormal plasma cells. I had 10 to 20%  of abnormal plasma cells, enough to be diagnosed with Smoldering Multiple Myeloma. At this stage, it is considered pre-cancerous and not treated, just monitored. A large percentage of people at this stage do not ever move into active Multiple Myeloma. For the next seven years, I was monitored by a hematologist every three months.   Depending on what my blood test levels showed, I had biopsies, PET scans, and MRIs during this time. 

In February 2021, I had a bone marrow MRI, and a lesion (tumor) was seen on my posterior iliac crest; the lesion was biopsied and was confirmed to be a plasmacytoma caused by the Myeloma. I did 25 targeted radiation treatments in April 2021 on the lesion, and it was found on later MRIs to have been effective.

In June of this year, my blood levels had increased close to double what they had been a year ago, I went to the Mayo Clinic in Rochester for a second opinion and the decision was made to start treating the Myeloma before it began to cause damage to any of my other major organs. 

My treatment consists of 16 weeks of 4 Chemotherapy drugs, 3 of which are delivered via subcutaneous injection (injected into my stomach) weekly, and one is an oral pill that I take 21 days out of every month. I also take three anti-bacterial drugs daily to help prevent infection, as my immune system is compromised. After completing the 16 weeks of induction therapy, I will have a bone marrow biopsy and scan to ensure that the chemo effectively decreased the myeloma levels. I will then be scheduled for a Stem Cell Transplant.

The simple version of the stem cell transplant is that my stem cells will be collected from my blood; the blood passes through a machine that separates and removes the stem cells. The rest of the blood is immediately returned to me, and the stem cells are then frozen and stored in liquid nitrogen. When cleared for the next step, I will be admitted into the hospital, where I will be given a high-dose round of chemotherapy to kill any remaining myeloma cells. One to two days later, the collected stem cells are unfrozen and returned to the bloodstream through an intravenous catheter. The stem cells travel through the bloodstream to the bone marrow, producing new blood cells. The average chemotherapy, transplant, and recovery time is 2 to 3 weeks in the hospital, but I will need to stay in Sioux Falls for a total of 30 days  with someone with me, 24 hours a day. When I get home, my immune system will be at close to zero, increasing slowly over the next 60 to 100 days.

For now we are moving forward one day at a time with faith and belief that the transplant will afford me many, many more years of life and in hope that a cure is on the horizon! I appreciate your thoughts and prayers for me and my family as we navigate through the next months.


Newest Update

Journal entry by Stacy Smith

The photo of me buckled up is from last Friday. It was my 31st day since my transplant, and I drove myself to Sioux Falls for my doctor's appointment🎉 The doctor was happy with my progress and how well things are going, so I don't have to return until March 8th! 
I only have stomach upset/nausea as a side effect of the chemo at this point, but that gets better and better every day. 

I also started back to work from home last week; I'm thankful to have that to help the days go by faster. Mike is also happy to have me back, as he was doing the driver recruiting while I was out; he has a better appreciation of the time and work that that job takes 😁 (should I push for a raise?😄)

So now the challenge is...I feel good, but I still can't (shouldn't, I guess is a better word; ultimately, it is my decision) be out and about in busy places or socialize in large groups due to my weak immune system. I'm not sure if I shared this already, but I have to get all of my childhood vaccinations plus any others again 😟 at six months post-transplant. Crazy that the transplant wiped all that clean.

Now, on to losing my hair. My hair has always been deeply intertwined with my identity, and it was emotional when Mike shaved it off in the hospital, but we had fun with it, too; we have some pretty funny videos and pictures of the process. I am choosing to embrace the bald as emblematic of my journey. The picture I share is what I sent to Mike and the kids this morning 😆

I won't post an update until after my next appointment in March unless something else comes up. Thank you all again, for the prayers, thoughts, and incredible support that you have given me over these last months 🙌💗 I am truly blessed in every way.

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