Allen Parkes's Journal
Written Nov 2, 2012 7:05pm by Allen Parkes
When I say last stand and multi drug approach in my last entry, it may have implied that I am giving up or am throwing a hail mary. Things aren't always as they seem. I am sorry that I didn't fully communicate what is going on. It is not a blind shot, but a guided approach to the multi-drug attack.
My tumor tissue has been submitted to two companies that do Genomic profiling of tissue to match patients with therapies based on molecular changes in the DNA of the tumor. In other words, the genetic mutations in the tissue that are responsible for the cancer are identified, and then therapies are identified that target these specific protein receptors that need to be shut down. One of these companies has identified two protein blocking drugs that may block the specific proteins in my genomic profile (EGFR and mTOR receptors). The other company has tested the responsiveness to various chemo-therapies and has confirmed that I should be responsive to the chemo that I am currently on. The fact that I seemed somewhat defeated previously, is a result of the tiring treatment and failure process to which I have grown accustomed. I feel like the multiple attack method is more than a guess by a drug company (clinical trial). It is an educated decision based on actual genetic response testing to all three drugs. My hope is that I can prove this theory correct.
Written Nov 2, 2012 12:04pm by Allen Parkes
After you get bad news all the time, it just becomes news. Much like the 11 o'clock news is just the news but is filled with negativity. I once again have been given news. My current trial at UCLA has ended due to the fact that the two tumors are growing quite rapidly. It failed. One has doubled its size in the 40 days since the trial began. I mentioned before that 3 other treatment options were lined up in the event that this happened. I am working through these currently. I feel a bit like I am on my last stand with this fight. I am not giving up and will continue to fight with everything I have. I am planning to throw everything I have left at it, in a multi-drug approach to overwhelm what is left of the cancer. As a result, I may look a little tired, aged and puffy. May have a little less hair (shouldn't surprise anyone). The usual chemo stuff I guess.
With that said, I am aware that my options are thinning. It is increasingly difficult to be realistic and maintain optimism in every day decisions while these choices wane. Here is where my energy is spent. I hope that the news is positive next time around.
Thank you to the Avnet folks and supplier/rep partners who sent me the biggest card I have ever seen. My kids were as surprised by it, as they were by Debra dressed up in her Angry bird costume. Thank you everyone! There are so many friends that I haven't seen in such a long time. You put a smile on all of our faces! Thank you!!
Thanks also to GB and Mark for your help to build a secret hideout for Ethan and Brandon. They love it!
Written Oct 24, 2012 8:43pm by Allen Parkes
I have just now been catching up on guestbook entries and trying to enter something, but with nothing much good to write about, I have been waiting patiently. I had all my chips in on the stem cell bet but once again I am disappointed. I seem to have traded in one large tumor for two small ones. These are residual cells left in the original general location. I'm still not sure which is worse....one big, or two little?? I am moving forward with my philosophy in the same exact way regardless. I am enrolled in another clinical trial for a protein blocking drug at UCLA. I will never know if something will eventually work unless I give it a shot. It's getting a little tiring but I am still looking for the one. In fact 3 new ones are lined up in case this one doesn't work. I'm not having a whole lot of success but I still feel like I am trying to keep one step ahead of this thing and this gives me a certain amount of piece-of-mind. I believe that all of the previous surgeries and trials have at least slowed the progress of this disease and may have given me more time.
Its been a little crazy the last couple months during the approval process for this trial and as a result I have not been keeping up with my Caring Bridge duties. For this I apologize. Thanks for the guestbook entries during this time. I really appreciate all of the continued support on-line and otherwise. My family, neighborhood and co-workers/friends continue to give me watery eyes with the unending moral and spiritual support they offer. It's very humbling.
Thank you from my heart!
Millsy, I just now caught up on messages on this site. It broke my heart to hear about your wife. I hope that everything is going well for your family. My number is 619-287-1958 if you need anything. We will all be sending you and your family positive thoughts and energy. I look forward to a great update from you!