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Chris Sanderson, age 38, was diagnosed with a grade IV glioma, malignant brain tumor, Glioblastoma Multiforme in December 2008. He has a wife, Brogann, and two little girls, Stevie (6) and Clementine (4). He coaches professional lacrosse and runs his own lacrosse business.
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10/15/08 grand mal seizure, MRI – benign tumor left frontal/temporal lobe grade 1
12/9/08 MRI – significant growth concerning for GBM
12/22/08 Craniotomy with gross total resection at Duke University Medical Center by Dr. Allan Friedman, pathology GBM
1/12/09 – 2/23/09 6 weeks radiation therapy w/ Dr. Lustig at UPENN with concurrent low dose Temodar and Avastin every 2 weeks
3/17/09 Started on patient specific regimen including EGFRvIII peptide vaccine, Temodar 200mg/m@ daily for 5days/mo, Bevacizumab 10 mg/kg every 2 weeks. Care managed for 2 years by Dr. David Reardon (Duke, later Dana Farber) and Dr. Peter Phillips (CHOP/UPenn).
3/14/11 s/p 24 cycles of Temodar 200 mg/m2 for 5 days/mo and s/p 27 doses of Avastin every 2 weeks. MRI showed enhancement, PET showed increased metabolic activity. Biopsy to confirm recurrence scheduled with Dr. Friedman at Duke.
3/17/11 biopsy of left temporal area by Dr. Friedman at Duke. Pathology c/w recurrent GBM, MGMT promoter methylated, IDH 1 negative
3/25/11 Gross total resection by Dr. John Yu at Cedars-Sinai Medical Center. Dendritic Cell Vaccine with Imiquimod started.
4/13/11-4/15/11 Radiosurgical boost by Dr. Lustig and UPenn while awaiting vaccine trial
5/13, 5/27, 610/11 Dendritic Cell Vaccine with Imiquimod trial at Cedar-Sinai Medical Center. Discontinued trial and resumed Avastin.
7/28/11 Resumed systemic therapy with Avastin with Dr. Reardon at Dana Farber Cancer Institute. Daily Etoposide and daily Verinostat both attempted but poorly tolerated and discontinued.
11/15/11 MRI showed new enhancement.
12/20/11 Underwent biopsy with injection of Tocagen and started Flucytosine regimen as part of Tocagen trial with Dr. Vogelbaum. 2 doses of Flycytosine until 2/22/12
3/15/12 MRI showed tumor progression. Tocagen trial discontinued.
3/22/12 Craniotomy, partial resection (approx. 60%) debulking by Dr. Don O’Rourke at Hospital of the University of Pennsylvania.
4/12/12 Intraarterial Erbitux/Cetuximab infusion trial by Dr. John Boockvar at Weill Cornell Medical Center
4/26/12 Novocure Device, JFK Hospital in Edison NJ, Dr. Landolfi
5/15/12 Antisense trial, Dr. David Andrews, Thomas Jefferson University Hospital, Philadelphia, PA